![]() ![]() Chemicals and ReagentsġH NMR, 13C NMR, and DEPT spectra were recorded at 500 MHz for 1H and at 125 MHz for 13C, with a Bruker DRX 500 instrument in DMSO- solution. glyptostroboides and to isolate and identify the proanthocyanidin compounds in its active fractions. Hence, the present study was designed to evaluate the free radical scavenging capacity and antioxidant activity of the extracts from the bark of M. glyptostroboides and its active compounds. However, there is no report available in the literature on antioxidant properties of the bark of M. The total flavones extracts, essential oil, and some other chemical ingredients from this plant were proved to exhibit cardiovascular protective effect and antibacterial, antioxidant, and cytotoxic activities. Thus far, the flavonoids, terpenoids, lignins, carotenoids, steroids, norlignans, and phenylpropanoids in the stems and leaves as well as essential oil in floral cones of M. glyptostroboides are used as antimicrobic, analgesic, and anti-inflammatory drug for dermatic diseases. In the Chinese folk medicine, the leaves and bark of M. Now, it is mainly used as landscape tree and propagated in many parts of China and other countries. glyptostroboides in the south of China in the early 1940s was one of the greatest botanical discoveries of the 20th century. Metasequoia glyptostroboides Hu et Cheng (dawn redwood, Chinese redwood, or water fir in English and shui shan in Chinese) is the only living species in the genus Metasequoia Miki ex Hu et Cheng (Taxodiaceae), which is well known as a “living fossil” species. ![]() In view of its excellentfree radical scavenging capacity and antioxidant activity, Pycnogenol is now utilized throughout the world as a nutritional supplement and as a phytochemical remedy for various diseases ranging from chronic inflammation to circulatory dysfunction, including several impaired psychophysiological functions. Up to now, the most prominent phenolic antioxidant from tree bark is Pycnogenol, which is commercially extracted from French maritime pine Pinus pinaster and mainly composed of proanthocyanidins (from 65% to 75%). The tree bark, which is easily available throughout the year and even the waste residues of some industrial production (such as paper production), is usually rich in phenolic compounds. The phenolic compounds, extensively distributed in different parts of the plant, have been proved to be natural antioxidants. Therefore, the researches on antioxidants, especially exploration of potent natural compounds with low cytotoxicity from plants, have become an important branch of biomedicine. The oxidative damage is a crucial etiological factor implicated in several chronic human diseases, such as diabetes mellitus, cancer, cardiovascular diseases, atherosclerosis, arthritis, and neurodegenerative diseases, as well as in degenerative processes associated with aging. However, reactive oxygen species (ROS) are often overproduced under pathological conditions, resulting in oxidative stress. Oxidation is essential to many organisms for the production of energy to fuel biological processes. In addition, ten proanthocyanidins were isolated from MGEB, and six of them were firstly reported from this plant. Furthermore, MGEB could significantly protect against CCl 4 induced acute liver injury through inhibition of oxidative stress in mice. The fraction MGEB, which was obtained by 60% ethanol extraction and followed by a further separation with D101 resin column chromatograph, possessed the highest proanthocyanidin content and the highest free radical scavenging and antioxidant activities. We observed total of six extracts and fractions, which were easily obtained by water-ethanol extraction and followed by a further separation with D101 resin column chromatography, had significant DPPH radical, superoxide anion radical, and hydroxyl radical scavenging capacity, total antioxidative capacity (T-AOC), lipid peroxidation inhibitory activity, and metal ions chelating capacity. This study is the first to report the free radical scavenging capacity, antioxidant activity, and proanthocyanidin composition of the bark of M. Metasequoia glyptostroboides Hu et Cheng is the only living species in the genus Metasequoia Miki ex Hu et Cheng (Taxodiaceae), which is well known as a “living fossil” species. ![]()
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